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The Impacts of Albuminuria and eGFR on Cardiovascular Disease

Received: 14 May 2017     Accepted: 25 May 2017     Published: 11 July 2017
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Abstract

Albuminuria is often used as a surrogate marker for the risk of fatal and non-fatal events in clinical trials of antihyperglycemic medications or in antihypertensive therapy. Similarly, low estimated glomerular filtration rate (eGFR), which is a common manifestation of progressed diabetic nephropathy, has also been demonstrated to be an independent risk factor for cardiovascular events and death. Recent evidence suggests that both high albuminuria and low eGFR are independent risk factors for progressive kidney failure and cardiovascular disease. The purpose of this study was to investigate the impacts of albuminuria and low eGFR on the risk of cardiovascular disease. A cross-sectional design was used. Data were collected through adults’ health examinations by a hospital in a certain area in Pingtung County between 2011 and 2015. The health data base included participants’ basic information, physical examination and blood examination results. Use abbreviated modification of diet in renal disease, aMDRD (Abbreviated modification of diet in renal disease) formula to estimate eGFR. Use metabolic syndrome to define the criteria of rising blood pressure, blood sugar, blood lipids as an important cardiovascular disease (CVD) indicator and then calculation of the 10-year risk for CVD was completed using data from the Framingham Heart Study and a computer was used to determine risk values. In this study, ≤ 10% was defined as low risk, 11-20% was defined as moderate risk, and > 20% was defined as high risk. As albuminuria and eGFR approached critically high values, initially moderate and high 10-year risk levels for CVD tended to increase. Logistic regression analysis showed that patients with severe albuminuria and severe eGFR had higher risks of metabolic syndrome, abnormal waist circumference, hyperglycemia, reduced high-density lipoprotein cholesterol (HDL-C), hypertriglyceridemia, and elevated blood pressure. The study concluded that albuminuria and eGFR are risk factors for CVD and can increase a patient’s 10-year risk of CVD.

Published in American Journal of Health Research (Volume 5, Issue 4)
DOI 10.11648/j.ajhr.20170504.12
Page(s) 99-105
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2017. Published by Science Publishing Group

Keywords

Albuminuria, Glomerular Filtration Rate, Cardiovascular Disease, Metabolic Syndrome

References
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Cite This Article
  • APA Style

    Hao-Huan Hu, Chin-Wen Hsieh, Yu-Kuei Liao, Szu-Mei Hsiao, Pi-Li Lin, et al. (2017). The Impacts of Albuminuria and eGFR on Cardiovascular Disease. American Journal of Health Research, 5(4), 99-105. https://doi.org/10.11648/j.ajhr.20170504.12

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    ACS Style

    Hao-Huan Hu; Chin-Wen Hsieh; Yu-Kuei Liao; Szu-Mei Hsiao; Pi-Li Lin, et al. The Impacts of Albuminuria and eGFR on Cardiovascular Disease. Am. J. Health Res. 2017, 5(4), 99-105. doi: 10.11648/j.ajhr.20170504.12

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    AMA Style

    Hao-Huan Hu, Chin-Wen Hsieh, Yu-Kuei Liao, Szu-Mei Hsiao, Pi-Li Lin, et al. The Impacts of Albuminuria and eGFR on Cardiovascular Disease. Am J Health Res. 2017;5(4):99-105. doi: 10.11648/j.ajhr.20170504.12

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  • @article{10.11648/j.ajhr.20170504.12,
      author = {Hao-Huan Hu and Chin-Wen Hsieh and Yu-Kuei Liao and Szu-Mei Hsiao and Pi-Li Lin and Aih-Fung Chiu and Tsan Yang},
      title = {The Impacts of Albuminuria and eGFR on Cardiovascular Disease},
      journal = {American Journal of Health Research},
      volume = {5},
      number = {4},
      pages = {99-105},
      doi = {10.11648/j.ajhr.20170504.12},
      url = {https://doi.org/10.11648/j.ajhr.20170504.12},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajhr.20170504.12},
      abstract = {Albuminuria is often used as a surrogate marker for the risk of fatal and non-fatal events in clinical trials of antihyperglycemic medications or in antihypertensive therapy. Similarly, low estimated glomerular filtration rate (eGFR), which is a common manifestation of progressed diabetic nephropathy, has also been demonstrated to be an independent risk factor for cardiovascular events and death. Recent evidence suggests that both high albuminuria and low eGFR are independent risk factors for progressive kidney failure and cardiovascular disease. The purpose of this study was to investigate the impacts of albuminuria and low eGFR on the risk of cardiovascular disease. A cross-sectional design was used. Data were collected through adults’ health examinations by a hospital in a certain area in Pingtung County between 2011 and 2015. The health data base included participants’ basic information, physical examination and blood examination results. Use abbreviated modification of diet in renal disease, aMDRD (Abbreviated modification of diet in renal disease) formula to estimate eGFR. Use metabolic syndrome to define the criteria of rising blood pressure, blood sugar, blood lipids as an important cardiovascular disease (CVD) indicator and then calculation of the 10-year risk for CVD was completed using data from the Framingham Heart Study and a computer was used to determine risk values. In this study, ≤ 10% was defined as low risk, 11-20% was defined as moderate risk, and > 20% was defined as high risk. As albuminuria and eGFR approached critically high values, initially moderate and high 10-year risk levels for CVD tended to increase. Logistic regression analysis showed that patients with severe albuminuria and severe eGFR had higher risks of metabolic syndrome, abnormal waist circumference, hyperglycemia, reduced high-density lipoprotein cholesterol (HDL-C), hypertriglyceridemia, and elevated blood pressure. The study concluded that albuminuria and eGFR are risk factors for CVD and can increase a patient’s 10-year risk of CVD.},
     year = {2017}
    }
    

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  • TY  - JOUR
    T1  - The Impacts of Albuminuria and eGFR on Cardiovascular Disease
    AU  - Hao-Huan Hu
    AU  - Chin-Wen Hsieh
    AU  - Yu-Kuei Liao
    AU  - Szu-Mei Hsiao
    AU  - Pi-Li Lin
    AU  - Aih-Fung Chiu
    AU  - Tsan Yang
    Y1  - 2017/07/11
    PY  - 2017
    N1  - https://doi.org/10.11648/j.ajhr.20170504.12
    DO  - 10.11648/j.ajhr.20170504.12
    T2  - American Journal of Health Research
    JF  - American Journal of Health Research
    JO  - American Journal of Health Research
    SP  - 99
    EP  - 105
    PB  - Science Publishing Group
    SN  - 2330-8796
    UR  - https://doi.org/10.11648/j.ajhr.20170504.12
    AB  - Albuminuria is often used as a surrogate marker for the risk of fatal and non-fatal events in clinical trials of antihyperglycemic medications or in antihypertensive therapy. Similarly, low estimated glomerular filtration rate (eGFR), which is a common manifestation of progressed diabetic nephropathy, has also been demonstrated to be an independent risk factor for cardiovascular events and death. Recent evidence suggests that both high albuminuria and low eGFR are independent risk factors for progressive kidney failure and cardiovascular disease. The purpose of this study was to investigate the impacts of albuminuria and low eGFR on the risk of cardiovascular disease. A cross-sectional design was used. Data were collected through adults’ health examinations by a hospital in a certain area in Pingtung County between 2011 and 2015. The health data base included participants’ basic information, physical examination and blood examination results. Use abbreviated modification of diet in renal disease, aMDRD (Abbreviated modification of diet in renal disease) formula to estimate eGFR. Use metabolic syndrome to define the criteria of rising blood pressure, blood sugar, blood lipids as an important cardiovascular disease (CVD) indicator and then calculation of the 10-year risk for CVD was completed using data from the Framingham Heart Study and a computer was used to determine risk values. In this study, ≤ 10% was defined as low risk, 11-20% was defined as moderate risk, and > 20% was defined as high risk. As albuminuria and eGFR approached critically high values, initially moderate and high 10-year risk levels for CVD tended to increase. Logistic regression analysis showed that patients with severe albuminuria and severe eGFR had higher risks of metabolic syndrome, abnormal waist circumference, hyperglycemia, reduced high-density lipoprotein cholesterol (HDL-C), hypertriglyceridemia, and elevated blood pressure. The study concluded that albuminuria and eGFR are risk factors for CVD and can increase a patient’s 10-year risk of CVD.
    VL  - 5
    IS  - 4
    ER  - 

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Author Information
  • Division of Nephrology, Pingtung Christian Hospital, Pingtung, Taiwan

  • Division of Nephrology, Pingtung Christian Hospital, Pingtung, Taiwan

  • Department of Nursing, Pingtung Christian Hospital, Pingtung, Taiwan

  • Department of Nursing, Meiho University, Pingtung, Taiwan

  • Department of Nursing, Meiho University, Pingtung, Taiwan

  • Department of Nursing, Meiho University, Pingtung, Taiwan

  • Department of Health Business Administration, Meiho University, Pingtung, Taiwan

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